Computational Biologist

Dubai, United Arab Emirates

https://www.mncjobsgulf.com/company/manpowergroup

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Job Description

We are currently looking for a Senior Computational Biologist, you will lead the in-silico discovery, modeling, and optimization of antibodies and novel binding proteins (e.g., nanobodies, affibodies, aptamers) tailored for rapid diagnostic test formats such as lateral flow assays and paper-based nucleic acid amplification systems. You will integrate structural bioinformatics and molecular simulation techniques to design high-affinity, high-specificity binders suited to point-of-care use.
Key Responsibilities:

Binder Design & Optimization:

- Perform in silico screening and affinity maturation of antibody candidates and alternative scaffolds for diagnostic use.
- Design and optimize CDR regions using structure-guided and AI-based techniques.
- Predict binding affinities and cross-reactivity using docking and molecular dynamics simulations.

Computational Pipeline Development:

- Develop and manage scalable pipelines for antibody-antigen modeling, docking, and binder optimization.
- Automate sequence-to-structure modeling and ML-based ranking of candida

Diagnostic Relevance:

- Tailor designs for rapid test constraints such as surface immobilization, lateral flow compatibility, and low-resource settings.
- Collaborate with wet-lab teams to iteratively test and refine computational designs.

Cross-functional Collaboration:

- Work closely with protein engineering, assay development, and molecular biology teams.
- Contribute to strategic decisions on antigen targets and binder formats

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